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Chemical Name: 7-(3
127(2):287-289
Homosalate (HMS
InChi: InChI=1S/C24H25N5O3S/c1-15(2)33(30
5-dioxa-13-azatetracyclo[7
mTOR-IN-1 - CAS# 1207358-59-5 Catalog No.:M9817-2 Chemical Name: 7-(3mTOR IN 1 is a remarkably selective mTOR inhibitor with a Ki of 1. 5 nM. mTOR IN 1 suppresses mTORC1 and mTORC2 in cellular and in vivo pharmacokinetic (PK) pharmacodynamic (PD) experiments. In Vitro: mTOR IN 1 (Compound 12i) inhibits mTOR with a Ki of 1. 5 nM, 500 fold selectivity over closely related PI3 kinases. mTOR IN 1 inhibits NCI PC3 and MCF7neo Her2 cells proliferation with IC50s of 150 nM and 57 nM, respectively[2]. In Vivo: mTOR IN 1