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Methoxy-X04 retains in vitro binding affinity for amyloid beta (Abeta) fibrils (Ki = 26
Molecular Weight: 386
PubMed PMID: 10726989
InChiKey: WEVYNIUIFUYDGI-UHFFFAOYSA-N
ID-8 was used at 0
MI-2 - Menin-MLL Inhibitor. CAS# 1271738-62-5 60033 Methoxy-X04 retains in vitro bindingMI 2, CAS No. 1271738 62 5, is a potent and specific Menin MLL inhibitor with an IC50 ~446 nM. It specifically binds to Menin and inhibits Menins interaction with MLL fusion proteins in cells. It can effectively reverse MLL fusion proteinmediated leukemic transformation by downregulating the expression of target genes downstream of MLL fusion protein oncogenic activity. MI 2 is a new tool for better understanding MLL mediated leukemogenesis and
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