Atuveciclib (BAY-1143572) magacestat (LY450139) CC1=CC(N)=C2C=CC=CC2=[N+]1CCCCCCCCCC[N+]1=C2C=CC=CC2=C(N)C=C1C

CC1=CC(N)=C2C=CC=CC2=[N+]1CCCCCCCCCC[N+]1=C2C=CC=CC2=C(N)C=C1C

R)-Noscapine hydrochloride

O=C([C@@H](CC1C=C(C=CC=1)C(F)(F)F)NS(=O)(=O)C1=CC(F)=C2CNCCC2=C1)N1CCCC1

is a non-nucleoside polymerase inhibitor currently under clinical trials for the treatment of Hepatitis C

selective and orally active apoptosis signal-regulating kinase 1 (ASK1) inhibitor with an IC50 of 14 nM

Atuveciclib (BAY-1143572) magacestat (LY450139) CC1=CC(N)=C2C=CC=CC2=[N+]1CCCCCCCCCC[N+]1=C2C=CC=CC2=C(N)C=C1CAtuveciclib (BAY 1143572) is potent and highly selective PTEFb CDK9 inhibitor with IC50 values of 13 nM for CDK9 CycT and the ratio of IC50 values for CDK2 CDK9 is about 100. Outside the CDK family, It inhibits GSK3 kinase with IC50 values of 45 nM and 87 nM for GSK3 and GSK3 respectively. Product information CAS Number: 1414943 88 6 Molecular Weight: 387. 43 Formula: C18H18FN5O2S Chemical Name: [(3 {[4 (4 fluoro 2 methoxyphenyl) 1,3,5 triazin 2