SCH-1473759 Size:Solid 10 mg and general exam) or at

and general exam) or at necropsy

4-difluorophenyl)methyl]-N-[(1R)-2-[(2

also known as INNO-206 and Doxo-EMCH

InChiKey: DWKVCQXJYURSIQ-UHFFFAOYSA-N

slowing their dissolution and inhibiting the formation and aggregation of these crystals

SCH-1473759 Size:Solid 10 mg and general exam) or atSCH 1473759 is a potent and selective Aurora A B inhibitor with IC50 sub nanomolar. SCH 1473759 was active against a large panel of tumor cell lines from different tissue origin and genetic backgrounds. SCH 1473759 demonstrated potent mechanism based activity, and activity was shown to be enhanced in combination with taxanes and KSP inhibitors. This information may be useful for optimizing the clinical efficacy of Aurora inhibitors. Product