Caspase-3/7 Inhibitor I Catalog No.:M23015-C CN(CC(O)COC1C=CC(=CC=1)NS(C)(=O)=O)CCC1C=CC(Cl)=C(Cl)C=1

CN(CC(O)COC1C=CC(=CC=1)NS(C)(=O)=O)CCC1C=CC(Cl)=C(Cl)C=1

11aS)-1-acetyl-9b-hydrogenio-7-{[(2R

CAS Number: 827318-97-8

splenomegaly

Oridonin (5

Caspase-3/7 Inhibitor I Catalog No.:M23015-C CN(CC(O)COC1C=CC(=CC=1)NS(C)(=O)=O)CCC1C=CC(Cl)=C(Cl)C=1Caspase 3 7 inbibitor I is a potent, reversible, isatin sulfonamide based inhibitor of caspase 3 (KI(app) = 60 nM) and caspase 7 (KI(app) = 170 nM). Is a weaker inhibitor of caspase 9 (Ki(app) = 3. 1 mM). It Has only a trivial effect (Ki(app) >25 mM) on the activities of caspase 1, caspase 2, caspase 4, caspase 6, and caspase 8. It has been shown to inhibit apoptosis in camptothecin treated Jurkat cells (IC50 ~50 M). Also it has been reported to