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InChiKey: GEPYBHCJBORHCE-SFHVURJKSA-N
16(11):1069-79
1 mg/kg results in efficacy comparable to that of naproxen at 10 mg/kg in a rat model of inflammatory pain
Compound 401 is a potent inhibitor of DNA-PK (IC50=0
but was found to be ineffective
FLI-06 - Notch Pathway Modulator. CAS# 313967-18-9 Catalog No.:M60149-10S InChiKey: GEPYBHCJBORHCE-SFHVURJKSA-NFLI 06, CAS No. 313967 18 9, is a novel potent and selective small molecule intercepting Notch signaling and the early secretory pathway (EC50 ~2. 3 M), identified by using automated microscopy to monitor the trafficking and processing of a ligand independent Notch GFP fusion reporter. FLI 06 can induce accumulation of the reporter at the plasma membrane by interfering with transport in the secretory pathway. It can also disrupt the Golgi apparatus in
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