SAG - Hedgehog Agonist. CAS# 912545-86-9 size:2 mg solid IOX4 could be a useful

IOX4 could be a useful tool compound for studies aimed at validating the upregulation of HIF for treatment of cerebral diseases including stroke

9(12):2126-39

S3I-201 (NSC-74859) preferentially inhibits Stat3 DNA-binding activity over that of Stat1 (IC50 values

and induces caspase-dependent apoptosis in leukemic cells but not in normal immature CD34+ cells

CAS Number: 1118807-13-8

SAG - Hedgehog Agonist. CAS# 912545-86-9 size:2 mg solid IOX4 could be a usefulSAG, CAS NO. 912545 86 9, is a potent, selective, and cell permeable small molecule agonist of the Hedgehog pathway. It modulates the coupling of Smo with its downstream effector by interacting with the Smo heptahelical domain (KD = 59 nM). SAG induces Hedgehog pathway activation with an EC50 of ~3 nM in NIH 3T3 derived Shh LIGHT2 cells and counteracts Cyclopamine KAAD inhibition of Smo. It was reported that SAG acts as an activator at low