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It is part of a range of functionalized tool molecules for PROTAC R&D
78(13 Suppl):Abstract nr 4958
InChi: InChI=1S/C24H38O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-18-21-19-17-20-22(25)23(21)24(26)27/h7-8
3(2H)-dione
InChiKey: NMKJFZCBCIUYHI-UHFFFAOYSA-N
MAK-683 - CAS# 1951408-58-4 Catalog No.:M7137-2 It is part of aMAK 683, CAS No. 1951408 58 4, is a potent inhibitor of embryonic ectoderm development protein (EED) and allosteric inhibitor of polycomb repressive complex 2 (PRC2), with potential antineoplastic activity. Upon administration, MAK683 selectively binds to the domain of EED that interacts with trimethylated lysine 27 on histone 3 (H3K27me3), which leads to a conformational change in the EED H3K27me3 binding pocket and prevents the interaction of EED