4SC-202 free base xiben HCl InChi: InChI=1S/C23H25NO2/c1-16(2)24-14-13-23(3

InChi: InChI=1S/C23H25NO2/c1-16(2)24-14-13-23(3

Distrutti E

Smiles: CC1(C)[C@@H](O)CC(=O)O[C@@H](C[C@@H]2O[C@]2(C)CCC[C@H](C)[C@H](O)[C@@H](C)C1=O)/C(/C)=C/C1=CSC(C)=N1

9 μM in immortalized keratinocytes (HaCaT)

Int J Clin Pharmacol Ther

4SC-202 free base xiben HCl InChi: InChI=1S/C23H25NO2/c1-16(2)24-14-13-23(3Domatinostat, also known as 4SC 202, is an orally bioavailable benzamide and inhibitor of human class I histone deacetylases (HDACs) isoenzymes 1, 2 and 3, with potential antineoplastic activity. HDAC inhibitor 4SC 202 selectively binds to and inhibits class I HDACs leading to an accumulation of highly acetylated histones. This may result in an induction of chromatin remodeling, the selective transcription of tumor suppressor genes, and the tumor