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7-dihydroxy-6-methyl-3
and Kickxia lanigera
Chemical Name: 2-[(hydrogen phosphonatooxy)methyl]-1-hydroxy-4-(4-octylphenyl)butan-2-aminium
InChi: InChI=1S/C25H30O4/c1-20(12-8-14-22(3)16-18-24(26)27)10-6-7-11-21(2)13-9-15-23(4)17-19-25(28)29-5/h6-19H
polycythemia vera
AC-4-130 Catalog No.:M31939-C 7-dihydroxy-6-methyl-3AC 4 130 is a potent STAT5 SH2 domain inhibitor. AC 4 130 directly binds to STAT5 and disrupts STAT5 activation, dimerization, nuclear translocation, and STAT5 dependent gene transcription. AC 4 130 induces cell cycle arrest and apoptosis in FLT3 ITD driven leukemic cells. AC 4 130 has anti cancer activity and can efficiently block pathological levels of STAT5 activity in acute myeloid leukemia (AML). Product information CAS Number: 1834571 82 2
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