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to increase the intracellular levels of cAMP
an effect that may be due to nonspecific toxicity
It did not significantly inhibit tumorsphere formation in the breast cancer cell line SUM159
albeit not identical
17(9):2799-806
I-BET762 (GSK525762) - BET Inhibitor. CAS# 1260907-17-2 Catalog No.:M60154-10S to increase the intracellular levelsI BET762 (GSK525762), CAS No. 1260907 17 2, is a novel, highly potent, selective and cell permeable inhibitor of the bromodomain and extra terminal (BET) family protein BRD4 with an IC50 of ~35 nM. It suppresses the production of proinflammatory proteins by macrophages and blocks acute inflammation. It is highly selective over other bromodomain containing proteins. In vivo studies using I BET762 have demonstrated efficacy in a range of oncology and
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