BEZ235 - CAS# 915019-65-7 urinol Pharmacological and clinical overview of

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BEZ235 - CAS# 915019-65-7 urinol Pharmacological and clinical overview ofDactolisib, also known as BEZ235, is an orally bioavailable phosphatidylinositol 3 kinase (PI3K) inhibitor with potential antineoplastic activity. PI3K inhibitor BEZ235 specifically inhibits PIK3 in the PI3K AKT kinase (or protein kinase B) signaling pathway, which may trigger the translocation of cytosolic Bax to the mitochondrial outer membrane, increasing mitochondrial membrane permeability; apoptotic cell death may ensue. Bax is a member of the