PIM-447 dihydrochloride - CAS# 1820565-69-2 Catalog No.:M16461-C Smiles: C(C1=CC=CC=N1)N(CC1=CC=CC=N1)CCN(CC1=CC=CC=N1)CC1=CC=CC=N1

Smiles: C(C1=CC=CC=N1)N(CC1=CC=CC=N1)CCN(CC1=CC=CC=N1)CC1=CC=CC=N1

Solubility: DMSO : ≥ 34 mg/mL (51

At the transfected human α4β2 neuronal nAChR in K177 cells

TAS-116 has moderate terminal elimination half-life (t1/2=8

18)12-5-1-3-10-4-2-8-16-13(10)12/h1-6

PIM-447 dihydrochloride - CAS# 1820565-69-2 Catalog No.:M16461-C Smiles: C(C1=CC=CC=N1)N(CC1=CC=CC=N1)CCN(CC1=CC=CC=N1)CC1=CC=CC=N1PIM447 dihydrochloride (LGH447 dihydrochloride) is a potent, orally available, and selective pan PIM kinase inhibitor, with Ki values of 6, 18, and 9 pM for PIM1, PIM2, and PIM3, respectively. PIM447 dihydrochloride displays dual antimyeloma and bone protective effects. PIM447 dihydrochloride induces apoptosis. Product information CAS Number: 1820565 69 2 Molecular Weight: 513. 38 Formula: C24H25Cl2F3N4O Chemical Name: N {4 [(1R,3S,5S) 3 amino 5