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Treatment of MCL cell lines with EPZ015666 led to inhibition of SmD3 methylation and cell death
2008 Nov 1
InChiKey: LLJYFDRQFPQGNY-QINSGFPZSA-N
2013 Jul 15
including G protein-dependent activation of extracellular signal-regulated kinase 1 and 2 (ERK1/2) and recruitment of β-arrestin
TAS-116 - CAS# 1260533-36-5 Catalog No.:M6713-10 Treatment of MCL cell linesTAS 116, CAS No. 1260533 36 5, also known as Pimitespib, is a potent and selective inhibitor of heat shock protein 90 (Hsp90) subtypes alpha and beta, with potential antineoplastic and chemo radiosensitizing activities. TAS 116 specifically binds to and inhibits the activity of Hsp90 alpha and beta; this results in the proteasomal degradation of oncogenic client proteins, which inhibits client protein dependent signaling, induces apoptosis, and
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