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and HCT116 (KRAS mutant)
20(1):233-45
CPI203 could be dosed to the mice by oral administration at 5 mg/kg twice per day for 7 days
no formal name For the convenience of scientific communication
Smiles: CCC1=C(CC(=O)N(CCOC)CCOC)C(C(=O)C2=CC(OC)=C(C=C2)OCCN2CCOCC2)=C(O)C=C1O
Vinblastine sulfate Size:Solid 2 mg and HCT116 (KRAS mutant)Vinblastine is a natural alkaloid isolated from the plant Vinca rosea Linn. Vinblastine binds to tubulin and inhibits microtubule formation, resulting in disruption of mitotic spindle assembly and arrest of tumor cells in the M phase of the cell cycle. This agent may also interfere with amino acid, cyclic AMP, and glutathione metabolism; calmodulin dependent Ca++ transport ATPase activity; cellular respiration; and nucleic acid and lipid biosynthesis.