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a β-catenin pathway inhibitor
InChi: InChI=1S/C19H19N5O/c1-13-6-4-5-7-17(13)23-22-15-8-9-16(14(2)12-15)21-19(25)18-10-11-20-24(18)3/h4-12H
Ileal expression of ZO-1 is significantly up-regulated in INT-747-treated BDL rats
twice daily) causes an inhibition of tumor growth in NCr athymic mice bearing established SW620 human colorectal cancer xenografts
25 to 20 microM
Selonsertib free base - CAS# 1448428-04-3 0321 a β-catenin pathway inhibitorSelonsertib free base, CAS No. 1448428 04 3, also known as GS 4997, is an orally bioavailable inhibitor of apoptosis signal regulating kinase 1 (ASK1), with potential anti inflammatory, antineoplastic and anti fibrotic activities. GS 4997 targets and binds to the catalytic kinase domain of ASK1 in an ATP competitive manner, thereby preventing its phosphorylation and activation. GS 4997 prevents the production of inflammatory cytokines, down regulates
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