ON-01910 selective p38α PROTAC SB203580 inhibits p38-MAPK stimulation of

SB203580 inhibits p38-MAPK stimulation of MAPKAPK2 with an IC50 of approximately 0

PubMed Central PMCID: PMC4216756

CAS Number: 1802326-66-4

Formulation: 10% ethanol-Solutol

2015 Jan 26

ON-01910 selective p38α PROTAC SB203580 inhibits p38-MAPK stimulation ofON 01910 is a synthetic benzyl styryl sulfone analogue with potential antineoplastic activity. Polo like kinase 1 inhibitor ON 01910. Na inhibits polo like kinase1 (Plk1), inducing selective G2 M arrest followed by apoptosis in a variety of tumor cells while causing reversible cell arrest at the G1 and G2 stage without apoptosis in normal cells. This agent may exhibit synergistic antitumor activity in combination with other chemotherapeutic agents.