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CDK9-PROTAC is a cereblon mediated proteasomal degrader of CDK9
Formula: C29H44F3N3O6
L-Buthionine sulfoximine
with an IC50 of 140 nM
once every 3 days
Pyrimidine-indole hybrid Catalog No.:M34537-C CDK9-PROTAC is a cereblon mediatedPyrimidine indole hybrid is a compound that inhibits ciliogenesis and has the activity of antagonizing the Hedgehog signaling pathway by destabilizing microtubules. Pyrimidine indole hybrid exerts its biological effects by inhibiting ciliogenesis and deconstructing the stable form of tubulin. Pyrimidine indole hybrid has shown its unique mechanism of action in in vitro cell experiments and zebrafish embryo models, interfering with microtubule
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