PF-04995274 0270 azeliragon decreased brain amyloid in

azeliragon decreased brain amyloid in mice and improved their performance on behavior tests

and vascular regrowth contribute to the antitumor properties of dual mTORC1/mTORC2 inhibitors

InChiKey: NFCRBQADEGXVDL-UHFFFAOYSA-M

GLPG0187 is a potent inhibitor of osteoclastic bone resorption and angiogenesis

InChi: InChI=1S/C17H23N3O2/c1-10(2)16-17(22)19-12(9-21)7-11-8-18-13-5-4-6-14(15(11)13)20(16)3/h4-6

PF-04995274 0270 azeliragon decreased brain amyloid inPF 04995274 (PF 4995274) is a potent, high affinity, orally active and partial agonist of serotonin 4 receptor (5 HT4R) with EC50 of 0. 47 nM, 0. 36 nM, 0. 37 nM and 0. 26 nM for human 5 HT4A 4B 4D 4E, respectively. As for rat 5 HT4S 4L 4E, the EC50 is 0. 59 nM, 0. 65 nM and 0. 62 nM, respectively. PF 04995274 is brain penetrant and can be used for cognitive disorders associated with Alzheimer's disease. Product information CAS Number: 1331782 27 4