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16S)-6-hydroxy-16-{[(2R
Smiles: CC1(C)[C@H]2[C@@H]3C=C(C[C@@]4(O)[C@@H](C=C(C)C4=O)[C@@]3(O)[C@H](C)[C@@H](OC(=O)CCC)[C@@]12OC(=O)CCC)CO
A saponin component from Dipsacus asper wall
also known as Olbemox and K-9321
Chemical Name: (2E)-N-[2-(2-ethoxyphenyl)ethyl]-3-(7-methoxy-1H-indol-3-yl)prop-2-enamide
COTI-2 nositol 16S)-6-hydroxy-16-{[(2RCOTI 2, an anti cancer drug with low toxicity, is an orally available third generation activator of p53 mutant forms. COTI 2 acts both by reactivating mutant p53 and inhibiting the PI3K AKT mTOR pathway. COTI 2 induces apoptosis in multiple human tumor cell lines. COTI 2 exhibits antitumor activity in HNSCC through p53 dependent and independent mechanisms. COTI 2 converts mutant p53 to wild type conformation. Product information CAS Number: 1039455 84