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A series of gemcitabine phosphoramidate prodrugs are synthesized and screened for cytostatic activity in a range of different tumor cell lines
10-dihydroxy-1
but 2-5 mg/kg dose-dependently reduces the number of wiping movements
Trans-ISRIB is a potent and selective small molecule inhibitor of PERK signaling (IC50 ~5 nM) that can potently reverse the effects of eIF2α phosphorylation
CAS Number: 869807-57-8
IKK-IN-1 7-51 Trifluoroacetate A series of gemcitabine phosphoramidateIKK IN 1 is an inhibitor of IKK extracted from patent WO2002024679A1, compound example 18 13. Product information CAS Number: 406211 06 1 Molecular Weight: 431. 91 Formula: C22H26ClN3O4 Chemical Name: 7 [2 (cyclopropylmethoxy) 6 hydroxyphenyl] 5 (piperidin 4 yl) 1H,2H,4H pyrido[2,3 d][1,3]oxazin 2 one hydrochloride Smiles: Cl. OC1=CC=CC(OCC2CC2)=C1C1=CC(C2CCNCC2)=C2COC(=O)NC2=N1 InChiKey: PLLAQIZOLUOIRN UHFFFAOYSA N InChi: InChI=1S C22H25N3O4. ClH c26
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