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with a Ki value of 0
17-11-9-8-10-12-17)15-28-21(24)16-13-18(25-4)20(27-6)19(14-16)26-5
also known as ONO 1206 and OP1206
PF-4136309 is potent in inhibiting CCR2 mediated signaling events such as intracellular calcium mobilization and ERK (extracellular signal-regulated kinase) phosphorylation with IC50 values of 3
4-d]pyrimidin-6-yl}phenyl)-2-methylmorpholine-4-carboxamide
AP14145 hydrochloride Size:Contact [email protected] for quotation with a Ki value ofAP14145 hydrochloride is a potent KCa2 (SK) channel negative allosteric modulator with an IC50 of 1. 1 M for KCa2. 2 (SK2) and KCa2. 3 (SK3) channels. AP14145 hydrochloride inhibition strongly depends on two amino acids, S508 and A533 in the channel. AP14145 hydrochloride prolonged atrial effective refractory period (AERP) in rats and demonstrates antiarrhythmic effects in a Vernakalant resistant porcine model of atrial fibrillation (AF). Product
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