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PP-121 directly inhibits Bcr-Abl induced tyrosine phosphorylation
The half-life
48 hours) abrogates DOX-induced upregulation of mesenchymal markers and the downregulation of epithelial markers in human HCC cell lines
65(5):435-44
The mean cellular GI50 of CCT018159 across a panel of human cancer cell lines
(Rac)-Tavapadon 23583 PP-121 directly inhibits Bcr-Abl induced(Rac) Tavapadon ((Rac) PF 06649751) is a potent and selective noncatechol dopamine D1 receptor agonist. (Rac) Tavapadon displays potent full agonism in the GS activation assay as well as partial agonism in the arrestin2 recruitment assay (GS cAMP, EC50=0. 8 nM; arrestin2, EC50=68 nM). (Rac) Tavapadon has antiparkinsonian activity. Product information CAS Number: 1643462 64 9 Molecular Weight: 391. 34 Formula: C19H16F3N3O3 Chemical Name: (Rac) 1, 5
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