Emodin noprol 3 hours) does not induce

3 hours) does not induce general defects in clathrin-dependent and -independent intracellular membrane trafficking in HeLa

TL12-186 (10-10000 nM

(2000) Bioorg Med Chem Lett

It was dosed to diabetic ob/ob mice via oral gavage at 3-30 mg/kg once per day for 2 weeks

CAS Number: 827319-43-7

Emodin noprol 3 hours) does not induceEmodin (from Rheum emodi, a Himalayan rhubarb) is a purgative resin, 6 methyl 1,3,8 trihydroxyanthraquinone, from rhubarb, buckthorn and Japanese knotweed (Fallopia japonica syn. Polygonum cuspidatum). Emodin is being studied as a potential agent that could reduce the impact of type 2 diabetes. It is a potent selective inhibitor of the enzyme 11 HSD1. In studies in obese mice, emodin limits the effect of glucocorticoids and may therefore ameliorate