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Chemical Name: 1-(tert-butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3
Selective inhibition of JAK2-driven erythroid differentiation of polycythemia vera progenitors
CAS Number: 928659-17-0
Drug Improves Survival in Refractory Colorectal Cancer
with potential clinical and research applications in nontransgenic animals
KU-60019 B018304 Chemical Name: 1-(tert-butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3KU 60019 is a potent and selective ATM inhibitor. KU 60019 is 10 fold more effective than KU 55933 at blocking radiation induced phosphorylation of key ATM targets in human glioma cells. As expected, KU 60019 is a highly effective radiosensitizer of human glioma cells. KU 60019 inhibits the DNA damage response, reduces AKT phosphorylation and prosurvival signaling, inhibits migration and invasion, and effectively radiosensitizes human glioma cells