PCS1055 dihydrochloride Catalog No.:M32998-C OC1=CC2CCNCC(C=2C=C1O)C1C=CC=CC=1

OC1=CC2CCNCC(C=2C=C1O)C1C=CC=CC=1

Smiles: C[C@@]12O[C@H]1[C@H](C)[C@@H]1C[C@@](O)(NC(=O)O1)[C@@H](C=CC=C(C)CC1C=C(C(Cl)=C(C=1)OC)N(C)C(=O)C[C@@H]2OC(=O)[C@H](C)N(C)C(=O)CCCCCN1C(=O)C=CC1=O)OC |c:17

or 2 g of Poloxamer 407 in 10 mL DMSO to make a 20% (w/v) stock solution

3)12(10)17)11(16)14(4

3% (average value) of all organic acids

PCS1055 dihydrochloride Catalog No.:M32998-C OC1=CC2CCNCC(C=2C=C1O)C1C=CC=CC=1PCS1055 dihydrochloride is a potent, selective and competitive muscarinic M4 receptor antagonist with an IC50 of 18. 1 nM and a Kd of 5. 72 nM. PCS1055 dihydrochloride inhibits radioligand [3H] NMS binding to the M4 receptor with a Ki of 6. 5 nM. PCS1055 dihydrochloride exhibits >100 fold selectivity over M1 , M3 , and M5 receptors and 30 fold selectivity at the M2 receptor. PCS1055 dihydrochloride is also a potent AChE inhibitor with IC50 s of 22 nM