BIBU 1361 dihydrochloride Catalog No.:M21988-C 7-4-2-1-3-5(8)6(9)10/h1-9H

7-4-2-1-3-5(8)6(9)10/h1-9H

50)51)20-22-33(31)44(35)25-14-10-13-18-36(45)40-23-15-24-41-42-39/h7-9

7-4-8-18(14

4-dinitrobenzene

cell degranulation

BIBU 1361 dihydrochloride Catalog No.:M21988-C 7-4-2-1-3-5(8)6(9)10/h1-9HBIBU 1361 dihydrochloride is a selective inhibitor of epidermal growth factor receptor (EGFR) kinase with an IC50 value of 0. 038 0. 007 M [1, 2]. The EGFR signaling pathway is associated with multiple intracellular signaling events that promote proliferation and survival. It plays a key role in the progression of glioblastoma multiforme (GBM) . In glioma cells, EGFR signaling can induce the phosphorylation of Akt, Erk1 2 and STAT3. BIBU 1361