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Structures and biological activities of the triterpenoids and sesquiterpenoids from Alisma orientale
to reduce anxiety-like behaviour and voluntary ethanol consumption in the iP (alcohol-preferring) rat
Calicheamicin is a DNA synthesis inhibitor
LY117018 exerts antiproliferative effects on breast cancer cell lines
Formula: C19H26ClF3N2O3
M3814 (nedisertib) 8445 Structures and biological activities ofNedisertib (M3814) is a potent and selective inhibitor of DNA dependent Protein Kinase (DNA PK), with an IC50 of <3 nM. Nedisertib (Compound 136) is a potent and selective inhibitor of DNA PK, with an IC50 of <3 nM for DNA PK and <0. 5 for cellular pDNA PK. In combination with IR, Nedisertib shows efficacy in all of the 6 mouse models of human cancer. In all models, a dose of 2 Gy administered daily for 1 week in combination with Nedisertib induces
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