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O=C1NS(=O)(=O)C2C=CC=CC1=2
with EC50s of 330 nM
2004 Dec 24
InChi: InChI=1S/C19H35BrO8/c1-2-4-21-6-8-23-10-12-25-14-16-27-18-19-28-17-15-26-13-11-24-9-7-22-5-3-20/h1H
or orally in a CWR22 human prostate tumor xenograft model in nude mice
PD-166793 2265 O=C1NS(=O)(=O)C2C=CC=CC1=2PD 166793 is a potent, selective, orally active and widebroad spectrum inhibitor of MMP, exhibiting nanomolar potency against MMP 2, MMP 3 and MMP 13 (IC50=4, 7, and 8 nM, respectively) and micromolar potency vs MMP 1, 7 and 9 (IC50=6. 0, 7. 2, and 7. 9 M, respectively). PD 166793 can attenuate left ventricular remodeling and dysfunction in a rat model of progressive heart failure. Product information CAS Number: 199850 67 4 Molecular Weight: 412. 30
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