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Smiles: OC(C1=CC(F)=C(C=C1)C1C=CC(CN2CCN(CC3C=CN=CC=3)CC2)=CC=1)(C(F)(F)F)C(F)(F)F
DCC-2618 targets and binds to both wild-type and mutant forms of KIT and PDGFRa specifically at their switch pocket binding sites
Reduction in mechanical pain threshold was also partially corrected by the treatment
MCT-14-1077
InChi: InChI=1S/C18H23NO4/c20-15-7-4-13(5-8-15)3-1-2-10-19-12-18(23)14-6-9-16(21)17(22)11-14/h4-9
(Rac)-BRD0705 - CAS# 1597440-03-3 Size:Contact [email protected] for quotation Smiles: OC(C1=CC(F)=C(C=C1)C1C=CC(CN2CCN(CC3C=CN=CC=3)CC2)=CC=1)(C(F)(F)F)C(F)(F)F(Rac) BRD0705 is a less active racemate of BRD0705. BRD0705 is a potent, paralog selective and orally active GSK3 inhibitor with an IC50 of 66 nM and a Kd of 4. 8 M. BRD0705 displays increased selectivity for GSK3 (8 fold) versus GSK3 (IC50 of 515 nM). BRD0705 can be used for acute myeloid leukemia (AML). Product information CAS Number: 1597440 03 3 Molecular Weight: 321. 42 Formula: C20H23N3O Chemical Name: 4 ethyl 7,7 dimethyl 4 phenyl