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PF-5274857 773 InChi: InChI=1S/C14H20Br2N2

SKU: 7229854383

4.3
USD120.00 USD146.00

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Description

InChi: InChI=1S/C14H20Br2N2

Water: 100 mg/mLwarmed(134

Nepafenac is a non-steroidal anti-inflammatory drug (NSAID)

8-fold increase in GPR120 mRNA expression

Chemical Name: (2-(4-chlorophenyl)quinolin-4-yl)(piperidin-2-yl)methanol

PF-5274857 773 InChi: InChI=1S/C14H20Br2N2PF 5274857 is a potent, orally active and selective hedgehog (Hh) signaling pathway inhibitor with an IC50 of 5. 8 nM and a Ki of 4. 6 nM. PF 5274857 was found to effectively penetrate the blood brain barrier and inhibit Smo activity in the brain of primary medulloblastoma mice, resulting in improved animal survival rates. PF 5274857 was orally available and metabolically stable in vivo. PF 5274857 is a potentially attractive clinical candidate for

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