AEE788 60258 6-Dichloro-3-Fluorophenyl)ethoxy]-5-(1-Piperidin-4-Ylpyrazol-4-Yl)pyridin-2-Amine

6-Dichloro-3-Fluorophenyl)ethoxy]-5-(1-Piperidin-4-Ylpyrazol-4-Yl)pyridin-2-Amine

Formula: C15H14Cl3N3O4

7 Suppl 3:12-9

Y-320 was administered orally at 0

5-triazin-4-yl]amino]-2-oxo-1-pyrrolidinyl]cyclohexyl]acetamide

AEE788 60258 6-Dichloro-3-Fluorophenyl)ethoxy]-5-(1-Piperidin-4-Ylpyrazol-4-Yl)pyridin-2-AmineAEE 788 is an orally bioavailable multiple receptor tyrosine kinase inhibitor. AEE788 inhibits phosphorylation of the tyrosine kinases of epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), and vascular endothelial growth factor receptor 2 (VEGF2), resulting in receptor inhibition, the inhibition of cellular proliferation, and induction of tumor cell and tumor associated endothelial cell apoptosis. Check for