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induces apoptosis in primary AML marrow blasts but not in normal myeloblasts
as well as NSCLC lung cancer
and may inspire novel drug discovery efforts aimed at the development of drugs targeting oncogenic RAS
3-dihydro(²H₅)-1H-indene-1
Chemical Name: 5-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1
Neratinib (HKI-272) vinostat) induces apoptosis in primary AMLNeratinib, also known as HKI 272 or PB272, is an orally available, irreversible inhibitor of the HER 2 receptor tyrosine kinase with potential antineoplastic activity. Neratinib binds to the HER 2 receptor irreversibly, thereby reducing autophosphorylation in cells, apparently by targeting a cysteine residue in the ATP binding pocket of the receptor. Product information CAS Number: 698387 09 6 Molecular Weight: 557. 04 Formula: C30H29ClN6O3 Synonym:
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