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and leukocyte migration
InChi: InChI=1S/C23H22N6O2/c24-10-12-25-22(30)18-3-1-17(2-4-18)21-9-11-26-23(28-21)27-19-5-7-20(8-6-19)29-13-15-31-16-14-29/h1-9
2 nM and IC90 of 40 nM
Smiles: COC1=CC(=CC=C1OC)C1=CC(=O)C2C(=CC(=CC=2O1)OC)OC
5-fold less sensitive than ALK5) but does not inhibit ALK2 at concentrations up to 10 μM
Aβ42-IN-1 free base 13437 and leukocyte migrationA42 IN 1 free base (compound 1v) is an orally active, high brain exposure secretase modulator. A42 IN 1 free base potently reduces A42 levels with an IC50 value of 0. 091 M, and significantly reduces brain A42 levels in mice. A42 IN 1 free base is a promising compound for the treatment of Alzheimers disease. Product information CAS Number: 2434633 17 5 Molecular Weight: 462. 54 Formula: C29H26N4O2 Chemical Name: 5 [8 ({[1,1' biphenyl] 4 yl}methoxy) 2
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