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R-GNE-140 - CAS# 2003234-63-5 size:2mg solid IWR-1 treatment in the presence

SKU: 82359833

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Description

IWR-1 treatment in the presence of maximal stimulatory dose of FSH (0

These results indicate that synthetic REV-ERB ligands that pharmacologically target the circadian rhythm may be beneficial in the treatment of sleep disorders as well as metabolic diseases

Ciprandi G

also known as E7010

PubMed Central PMCID: PMC3064743

R-GNE-140 - CAS# 2003234-63-5 size:2mg solid IWR-1 treatment in the presenceR GNE 140, CAS No. 2003234 63 5, a novel potent lactate dehydrogenase (LDHA) inhibitor with IC50 3nM for LDHA and 5 nM for LDHB. In MIA PaCa 2 human pancreatic cells, LDHA inhibition rapidly affected global metabolism, although cell death only occurred after 2 d of continuous LDHA inhibition. Pancreatic cell lines that utilize oxidative phosphorylation (OXPHOS) rather than glycolysis were inherently resistant to GNE 140, but could be resensitized to

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