UPF-648 Sodium Salt 436 5-a]pyrimidine-3-carbonitrile

5-a]pyrimidine-3-carbonitrile

3)19-11-13-20(14-12-19)29(24(31)21-10-8-16-32-21)22(18-9-7-15-27-17-18)23(30)28-26(4

4 mM PD0325901 and 1 mM CHIR99021 in DMSO

Selective inhibition of hypoxia-inducible factor 1α ameliorates adipose tissue dysfunction

Therrien JP

UPF-648 Sodium Salt 436 5-a]pyrimidine-3-carbonitrileUPF 648 is a potent kynurenine 3 monooxygenase (KMO) inhibitor; exhibits highly active at 1 uM (81 10% KMO inhibition); ineffective at blocking KAT activity. IC50 value: 1 uM(81 10 % inhibition) Target: KMO inhibitor in vitro: BFF 122 inhibited KAT activity almost completely at both 1 and 0. 1 mM. The effect was still remarkable at 0. 01 mM (70 1 % inhibition). Product information CAS Number: 1465017 87 1 Molecular Weight: 281. 07 Formula: