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InChi: InChI=1S/C13H20N2O4/c1-14-4-6-15(7-5-14)12(16)10-8-2-3-9(19-8)11(10)13(17)18/h8-11H
Knockdown of DR4 abolishes NF-κB activation
In syngeneic 129S1 mice
(S)-CVN424 is a potent G-Protein-Coupled Receptor 6 (GPR6) modulator
4(5):441-445
AES-350 - CAS# 847249-57-4 12841 InChi: InChI=1S/C13H20N2O4/c1-14-4-6-15(7-5-14)12(16)10-8-2-3-9(19-8)11(10)13(17)18/h8-11HAES 350 is a potent and orally active HDAC6 inhibitor with an IC50 and a Ki of 0. 0244 M and 0. 035 M, respectively. AES 350 is also against HDAC 3, 8, and 11 in an enzymatic activity assay with IC50 values of 0. 187 M, 0. 245 M, and >1M, respectively. AES 350 triggers apoptosis in AML cells through HDAC inhibition and can be used for acute myeloid leukemia (AML) research. Product information CAS Number: 847249 57 4 Molecular Weight: 312. 36 Formula: