K 01-162 nocitrin 2-b]pyridin-2-yl}-5-methoxy-N

2-b]pyridin-2-yl}-5-methoxy-N

2013 Aug 9

RET V804M-IN-1 (compound 5) exhibits 3

Ileal expression of ZO-1 is significantly up-regulated in INT-747-treated BDL rats

Identification and structure-function analysis of subfamily selective Gprotein-coupled receptor kinase inhibitors

K 01-162 nocitrin 2-b]pyridin-2-yl}-5-methoxy-NK 01 162 (K162) binds and destabilizes AO ( amyloid), with an EC50 of 80 nM. IC50 value: 80 nM (EC50) Target: Amyloid in vitro: The active drug candidate K162 (EC50 = 0. 080 M), stabilizes hydrophobic core I of A42 peptide (residues 17 21) to its helical conformation by interacting specifically in this region. K01 162 shows full MC65 protection at 125 nM, an EC50 of 80 nM, and no cytotoxicity up to 50 M. in vivoK01 162 can reduce the brain amyloid