4-Methyldaphnetin ecoxib-d7 Smiles: N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC2=CC=CC=C2C=C1)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H](CCCNC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC2C=CC(O)=CC=2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](CC2C=CC(O)=CC=2)NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O

Smiles: N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC2=CC=CC=C2C=C1)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H](CCCNC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC2C=CC(O)=CC=2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](CC2C=CC(O)=CC=2)NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O

infused into the lateral ventricle

2ClH/c1-16-7-8-18(15-17(16)2)25-13-11-24(12-14-25)10-9-21-19-5-3-4-6-20(19)22(26)23-21

5 mg/kg results in dose-dependent increase in TGI (73%

down-regulation of Bcl-2 and stimulating the release of Cyto-C from mitochondria in lung cancer cells

4-Methyldaphnetin ecoxib-d7 Smiles: N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC2=CC=CC=C2C=C1)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H](CCCNC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC2C=CC(O)=CC=2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](CC2C=CC(O)=CC=2)NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O4 Methyldaphnetin is a precursor in the synthesis of derivatives of 4 methyl coumarin. 4 Methyldaphnetin has potent, selective anti proliferative and apoptosis inducing effects on several cancer cell lines. 4 Methyldaphnetin possesses radical scavenging property and strongly inhibits membrane lipid peroxidation. Product information CAS Number: 2107 77 9 Molecular Weight: 192. 17 Formula: C10H8O4 Chemical Name: 7,8 dihydroxy 4 methyl 2H chromen 2 one