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RX-3117 - CAS# 865838-26-2 Catalog No.:M11354-10 It inhibits KDM2A at IC50

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Description

It inhibits KDM2A at IC50 ~1

Swearingen D

such as potentiating neuronal differentiation

Salinomycin (5 and 10 mg/kg) significantly supresses the average tumor volume and tumor weight

specifically at 305 μM

RX-3117 - CAS# 865838-26-2 Catalog No.:M11354-10 It inhibits KDM2A at IC50RX 3117, also known as TV 1360 and fluorocyclopentenylcytosine, is an orally available and potent DNA synthesis inhibitor with potential antineoplastic activity. Upon administration, the cytidine analogue RX 3117 is taken up by cells through a carrier mediated transporter, phosphorylated by uridine cytidine kinase (UCK) and then further phosphorylated to its diphosphate (RX DP) and triphosphate forms (RX TP). The triphosphate form is incorporated into

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