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442 (2002) 163-171
for human recombinant receptors)
This leads to an accumulation of unfolded and misfolded ubiquitinated proteins and may eventually induce cancer cell apoptosis
InChi: InChI=1S/C19H21NO5S/c1-11-8-15(21)18(19(22)25-11)14-10-17(26-7-6-20-14)13-5-4-12(23-2)9-16(13)24-3/h4-5
CN1CCN(CC2=CC(=CC=C2O)NC2C3=CC(=CC=C3N=C3C=C(Cl)C=CC3=2)OC)CC1
SAR-020106 22279 442 (2002) 163-171SAR 020106 is an ATP competitive, potent, and selective CHK1 inhibitor with an IC50 of 13. 3 nM for human CHK1. SAR 020106 shows excellent selectivity over CHK2. SAR 020106 significantly enhances the cell killing of Gemcitabine and SN38 by 3 to 29 fold in several colon tumor lines and in a p53 dependent fashion. SAR 020106 can enhance antitumor activity with selected anticancer drugs. Product information CAS Number: 1184843 57 9 Molecular Weight: 382.