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Smiles: CC1=NC=C(N1CCO)N(=O)=O
57(10):4333-40
Formula: C17H23NO3
SD-208 reduces the development and progression of melanoma bone metastases
IC50 value: 44 nMTarget: sigma receptorin vitro: PRE-084 has an IC50 of more than 100
FK 866 hydrochloride emodin Smiles: CC1=NC=C(N1CCO)N(=O)=OFK 866 hydrochloride is an inhibitor of nicotinamide phosphoribosyltransferase (NMPRTase) with IC50 values ranging between 0. 09nM and 27. 2nM . NAD plays a vital role in numerous biochemical and biologic processes. Targeting NAD synthesis is thought to be a selective manner to kill cancer cells since cancer cells have a higher rate of NAD turnover compared with normal cells. In the vitro MTT assay using a panel of 41 human hematologic cancer cell
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