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Jin Jiaojiao
35(4):713-23
effectively suppresses Src-mediated transformation by inhibiting both CDKs and c-Src
ABT-333 (Dasabuvir) is at least 7
Moxonidine may also promote sodium excretion
Palbociclib 1150 Jin JiaojiaoPalbociclib, also known as PD 0332991, is an orally available cyclin dependent kinase (CDK) inhibitor with potential antineoplastic activity. Palbociclib selectively inhibits cyclin dependent kinase 4 (CDK4) and 6 (CDK6), thereby inhibiting retinoblastoma (Rb) protein phosphorylation early in the G1 phase leading to cell cycle arrest. This suppresses DNA replication and decreases tumor cell proliferation. CDK4 and 6 are serine threonine kinases that
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