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BPTES has a K(i) of approx
Treatment with Anacetrapib leads to significant increases in HDL-C levels at day 0
GSK-5959 (3a) exhibits an EC50 = 0
Formula: C31H31N3O5
Cobalt chloride induces RhoA/ROCK activation and remodeling effect in H9c2 cardiomyoblasts: Involvement of PI3K/Akt and MAPK pathways
GW-627368X - CAS# 439288-66-1 ry of Histone Demethylase BPTES has a K(i) ofGW 627368X, CAS No. 439288 66 1, is a novel, potent and selective competitive antagonist of prostanoid EP4 receptors with additional human TP receptor affinity. Oral administration of GW627368X showed significant tumor regression characterized by tumor reduction and induction of apoptosis. Reduction in prostaglandin E2 synthesis also led to reduced level of VEGF in plasma. GW627368X will be a valuable tool to explore the role of the prostanoid EP4