From Stranglehold to Flickerwisp to Avarice Totem to Brand to Baral's Expertise, there are a lot o' ways to prevent your foe from Talisman'ing
In the end, I basically Time Walked myself as I had to wait another turn cycle to cast it
Some of Magics sweetest cards have been powerful instants and sorceries, whether you like ramping, burning out your opponent, countering spells, or blowing up the world, there are a ton of instants and sorceries that are right for you
However, that Commander's Sphere has use once you no longer need the mana it provides
Getting unconditional Swords to Plowshares on a creature is huge , especially because you can always cast it for the alternate cost
Players can also challenge any characters their opponent has exhausted, forcing them to exchange the characters health and strength with their own and potentially causing them to discard the card