A not-broken version of Alchemists Refuge for non-Simic decks
$25 Upgrade +1/+1 Counters is a very deep archetype so there's more sweet upgrade options that I could ever hope to cover, but I selected some of my favorites: for protection I've added Bulwark Ox and Mutational Advantage, a bunch of proliferates with Metastatic Evangel and Dreamtide Whale being the two best, ramp got a massive upgrade with Astral Cornucopia / Kami of Whispered Hopes / Purestrain Genestealer / Summon: Fenrir, and so on
Whenever chaos ensues, end the turn
For three mana, you get a Black and Green enchantment that deals one damage to you in your upkeep
Overall, this card is a draw engine, and if you build around it, the strategy is perfectly playable, even if it's not to most players' taste, especially as playing cards exerted can be risky against more aggressive decks
9 Lady Tremaine: Imperious Queen 211/204, Ruby Lady Tremaine: Imperious Queen forces an opponent to banish one of their own characters , so its best played when they only have strong cards to get rid of