If were looking at commanders which appreciate Gyruda for something other than instant wins, its mostly mill decks that are already heavy on creatures and recursion
Combo-Control - Play control and then win with a combo
While that's not the most terrible idea, the likelihood in a Niv-Mizzet deck is that the other spell you're casting is a burn spell that could do the same, and I have to feel that you're going to be better off casting it by itself, rather than putting all your eggs in one basket
However, Wrath of God says, Destroy all creatures. Because it doesnt target a specific creature, it applies to every creature on the battlefield, whether they have hexproof or not
Zombies There's definitely the potential for a powerful Zombies strategy in the current Standard
That meant the first set, Shadows over Innistrad , would be all about investigating strange occurrences, while the second set, Eldritch Moon , would be about horrors of the plane that have since been revealed