There exist multiple decks playing Urzas Saga, the most popular being Affinity, Amulet Titan and Hammer Time, and Force of Vigor can regularly destroy two permanents for zero mana in these matchups
Still behaving

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If we can benefit from any spell as long as it can be played on their turn, I want to load up on all of the 75% spells I can to make sure we're pilfering their cards, thus getting us even more value
Deeproot Historian, Bygone Marvels 2 graveyard recursion
Just keep casting your big creatures and so long as they have power 4 or greater, you'll be able to draw a card when they enter the battlefield