Life gain against aggressive strategies, card advantage against decks wanting to grind, mana to give you a needed explosive turn to catch up these are just some of the most useful functions it serves in different spots
The abilities of that half apply
Your deck has been priced in dollars, tix, and you have a rarity breakdown for MTG Arena

Abomination Abu Ja'far Akroma's Vengeance Amalia Benavides Aguirre Angrath, Minotaur Pirate Austere Command Avatar of Woe Avenge Awaken the Maelstrom Battering Ram Begin Anew Blight Grenade Blood Money Blood on the Snow Bontu's Last Reckoning Breaking Point Cacophony Unleashed Catastrophe Ceaseless Conflict Citywide Bust Cleanse Cleansing Nova Cloud's Limit Break Cockatrice Coils of the Medusa Crux of Fate Damnation Damning Verdict Day of Black Sun Day of Judgment Deadly Cover-Up Deadly Tempest Deadly Vanity Death Begets Life Death-Rattle Oni Deathbringer Regent Decree of Annihilation Decree of Pain Defiant Vanguard Depopulate Desolation Giant Devastation Do or Die Don't Move Doomskar Dread Cacodemon Drudge Spell Dusk // Dawn Elspeth, Sun's Champion End Hostilities Endemic Plague Expel the Interlopers Extinction Extinguish All Hope Fated Clash Fated Retribution Fell the Mighty Fight to the Death Final Act Final Showdown Finale of Eternity Flesh Allergy Force of Despair Forced March Fumigate Game Over Gaze of the Gorgon Genesis of the Daleks Giant Albatross Gideon Jura Gift of the Deity

Nezumi Bone-Reader The main issue with Nezumi Bone-Reader is that its ability can only be used as a sorcery
The key is to analyze the current metagame and anticipate what your deck is most likely to struggle against