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El-Deiry WS
The inhibition of USP7 is predicted to destabilize HDM2 and stabilize p53
InChi: InChI=1S/C27H27N5O2/c1-32(2)15-16-34-22-7-3-19(4-8-22)27-29-25(18-11-13-28-14-12-18)26(30-27)21-5-9-23-20(17-21)6-10-24(23)31-33/h3-5
(-)-Indolactam V shows Kds of 5
compoundwith 1-(2-(4-chlorobenzhydryloxy)ethyl)piperidine (1:1)
NVP-BEP800 Size:2mg solid El-Deiry WSNVP BEP800, also known as BEP 800, is a novel, fully synthetic, orally bioavailable inhibitor that binds to the NH(2) terminal ATP binding pocket of Hsp90. NVP BEP800 showed activity against a panel of human tumor cell lines and primary human xenografts in vitro at nanomolar concentrations. In A375 melanoma and BT 474 breast cancer cell lines, NVP BEP800 induced client protein degradation (including ErbB2, B Raf(V600E), Raf 1, and Akt) and Hsp70
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